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KMID : 0861020110260040083
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Korea Journal of Herbology
2011 Volume.26 No. 4 p.83 ~ p.88
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The Experimental study on the Immuno-regultory effect of Notopterygii Rhizoma Extract on OVA-induced asthma in mice
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Yoo Ji-Hyun
Bae Jin-Hyun
Doh Eun-Soo
Chang Jun-Pok
Seong Nak-Sul
Kill Ki-Jung
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Abstract
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Objectives: The aim of this study was to investigate the asthma-suppressive and immuno-regulatory effect of
Notopterygii Rhizoma(NR) extract on OVA(ovalbumin)-induced asthma in mice.
Methods: C57BL/6 mice out of all the experimental groups, except the Normal group and the NRⅠgroup, were
sensitized and challenged with OVA. C57BL/6 mice were exposed to OVA three times a week for 12 weeks and
analyzed by flow cytometer, ELISA, H&E stain.
Results: The concentrations of IL-4, IL-5, IL-13, IgE in serum of the OVA-NRⅡgroup decreased significantly
compared with those of the OVA-Control group. The number of Gr-1+/CD11b+, CCR3+, CD3+/ CD19+,
CD3e+/CD69+cells in the OVA-NRⅠ group decreased significantly compared with those of the OVA-Control
group. The collagen accumulation in the lung sections of the OVA-NRⅡ group decredased signi- ficantly
compared with that of the OVA-Control group.
Conclusions: These results suggest that Notopterygii Rhizoma(NR) would be a effective candidate for
herbal-originated anti-asthmatic drug. However, this drug should be further studied for characterization of the
accurate action and underlying mechanism using variant disease model in the future.
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KEYWORD
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Notopterygii Rhizoma, OVA(ovalbumin)-induced asthma, immune cell
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